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\/>\n\uff08\uff1a\u80ce\u513f\u7578\u5f62\u7387 \u598a\u5a20\u671f\u9ad8\u8840\u538b \u5507\u816d\u88c2\uff09<br \/>\n1. \u80da\u80ce\u53d1\u80b2\u5f71\u54cd<br \/>\n\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u961f\u5217\u7814\u7a76\u663e\u793a\uff1a\u6bcf\u65e5\u6444\u5165200mg\u4ee5\u4e0a\u5496\u5561\u56e0\u7684\u5b55\u65e9\u671f\u5973\u6027\uff0c\u80ce\u513f\u5507\u816d\u88c2\u53d1\u751f\u7387\u589e\u52a021%\uff08OR=1.21, 95%CI 1.02-1.43\uff09\u3002\u52a8\u7269\u5b9e\u9a8c\u8bc1\u5b9e\uff0c\u9ad8\u5242\u91cf\u5496\u5561\u56e0\uff08&gt;500mg\/kg\uff09\u53ef\u5bfc\u81f4\u5927\u9f20\u80da\u80ce\u795e\u7ecf\u7ba1\u53d1\u80b2\u5f02\u5e38\uff0c\u6b64\u5242\u91cf\u6298\u5408\u4eba\u4f53\u4e3a\u6bcf\u65e5\u7ea6400mg\u3002<\/p>\n<p>2. \u6d41\u4ea7\u4e0e\u65e9\u4ea7\u98ce\u9669<br \/>\n\u82f1\u56fd\u5987\u4ea7\u79d1\u6742\u5fd7\uff08BJOG\uff09Meta\u5206\u6790\u6307\u51fa\uff1a\u6bcf\u65e5\u5496\u5561\u56e0\u6444\u5165\u2265200mg\u53ef\u4f7f\u81ea\u7136\u6d41\u4ea7\u98ce\u9669\u589e\u52a018%\uff08RR=1.18\uff09\uff0c\u65e9\u4ea7\u98ce\u9669\u4e0a\u534724%\uff08RR=1.24\uff09\u3002\u673a\u5236\u7814\u7a76\u663e\u793a\u5496\u5561\u56e0\u53ef\u80fd\u901a\u8fc7\u6291\u5236COX-2\u9176\u5f71\u54cd\u524d\u5217\u817a\u7d20\u5408\u6210\uff0c\u5e72\u6270\u5bab\u7f29\u8282\u5f8b\u3002<\/p>\n<p>3. \u795e\u7ecf\u7cfb\u7edf\u53d1\u80b2<br \/>\n\u52a0\u62ff\u5927\u513f\u7ae5\u5065\u5eb7\u7814\u7a76\u6240\u8ffd\u8e2a\u7814\u7a76\uff1a\u5b55\u671f\u5496\u5561\u56e0\u6444\u5165\uff1e200mg\/\u65e5\u8005\uff0c\u65b0\u751f\u513f5\u5206\u949fApgar\u8bc4\u5206\u964d\u4f4e0.3\u5206\uff08\u03b2=-0.32, p&lt;0.05\uff09\u3002\u957f\u671f\u5f71\u54cd\u65b9\u9762\uff0c6\u6708\u9f84\u5a74\u513f\u8ba4\u77e5\u6d4b\u8bd5\u663e\u793a\uff0c\u9ad8\u5496\u5561\u56e0\u66b4\u9732\u7ec4\u5728\u89c6\u89c9\u8ffd\u8e2a\u4efb\u52a1\u4e2d\u53cd\u5e94\u65f6\u5ef6\u957f15ms\u3002<\/p>\n<p>\u4e09\u3001\u54fa\u4e73\u671f\u5496\u5561\u56e0\u66b4\u9732\u7684\u53cc\u91cd\u98ce\u9669<br \/>\n\uff08\uff1a\u4e73\u6c41\u4e2d\u6d53\u5ea6 \u5a74\u513f\u8840\u836f\u6d53\u5ea6 \u54fa\u4e73\u7b56\u7565\uff09<br \/>\n1. \u4e73\u6c41\u4f20\u9012\u7279\u5f81<br \/>\n\u5496\u5561\u56e0\u5728\u4e73\u6c41\u4e2d\u7684\u6d53\u5ea6\u4e0e\u6bcd\u4f53\u8840\u836f\u6d53\u5ea6\u5448\u6b63\u76f8\u5173\uff08r=0.78, p&lt;0.01\uff09\uff0c\u54fa\u4e73\u671f\u534a\u8870\u671f\u5ef6\u957f\u81f35-6\u5c0f\u65f6\u3002\u7f8e\u56fd\u513f\u79d1\u5b66\u4f1a\uff08AAP\uff09\u6307\u51fa\uff0c\u6bcd\u4eb2\u6bcf\u65e5\u6444\u5165200mg\u5496\u5561\u56e0\uff0c\u5a74\u513f\u65e5\u6444\u5165\u91cf\u53ef\u8fbe60-80mg\uff08\u7ea6\u5176\u4f53\u91cd5%\u7684\u66b4\u9732\u91cf\uff09\u3002<\/p>\n<p>2. \u5a74\u513f\u8010\u53d7\u6027\u5dee\u5f02<br \/>\n\u4e34\u5e8a\u76d1\u6d4b\u663e\u793a\uff0c20%\u7684\u5a74\u513f\u5bf9\u5496\u5561\u56e0\u4ee3\u8c22\u5b58\u5728\u57fa\u56e0\u591a\u6001\u6027\uff08CYP1A2*2\u7b49\u4f4d\u57fa\u56e0\u643a\u5e26\u8005\uff09\uff0c\u5176\u8840\u836f\u6d53\u5ea6\u53ef\u8fbe\u6b63\u5e38\u503c\u76842-3\u500d\u3002\u5178\u578b\u8868\u73b0\u4e3a\u54fa\u4e73\u540e4-6\u5c0f\u65f6\u51fa\u73b0\u6613\u6fc0\u60f9\u3001\u7761\u7720\u969c\u788d\u7b49\u4e2d\u6bd2\u75c7\u72b6\u3002<\/p>\n<p>3. \u5b89\u5168\u6444\u5165\u9608\u503c<br \/>\n\u6839\u636e\u300a\u4e2d\u56fd\u5c45\u6c11\u81b3\u98df\u8425\u517b\u7d20\u53c2\u8003\u6444\u5165\u91cf\u300b\uff0c\u54fa\u4e73\u671f\u6bcf\u65e5\u5496\u5561\u56e0\u5b89\u5168\u4e0a\u9650\u4e3a200mg\u3002\u5efa\u8bae\u5206\u6b21\u6444\u5165\uff1a\u6bcf\u676f\u5496\u5561\uff08240ml\uff09\u7ea6\u542b80-100mg\uff0c\u8336\u7c7b\uff08300ml\uff0920-45mg\uff0c\u80fd\u91cf\u996e\u6599\uff08350ml\uff0980-150mg\u3002<\/p>\n<p>\u56db\u3001\u4e34\u5e8a\u7ba1\u7406\u7b56\u7565\u4e0e\u66ff\u4ee3\u65b9\u6848<br \/>\n\uff08\uff1a\u9636\u68af\u5f0f\u51cf\u91cf\u6cd5 \u66ff\u4ee3\u996e\u54c1\u9009\u62e9 \u8425\u517b\u8865\u5145\u5242\uff09<br \/>\n1. \u68af\u5ea6\u76d1\u6d4b\u65b9\u6848<br \/>\n\u63a8\u8350\u5b55\u4e2d\u671f\uff0814-28\u5468\uff09\u8fdb\u884c\u5496\u5561\u56e0\u4ee3\u8c22\u80fd\u529b\u68c0\u6d4b\uff0c\u5bf9CYP1A2\u57fa\u56e0\u578b\u643a\u5e26\u8005\u5b9e\u65bd\u4e2a\u4f53\u5316\u7ba1\u7406\u3002\u5efa\u8bae\u91c7\u7528&quot;3-2-1&quot;\u51cf\u91cf\u6cd5\uff1a\u5b55\u665a\u671f\u524d3\u4e2a\u6708\u6bcf\u65e5\u76d1\u6d4b\uff0c\u524d2\u5468\u51cf\u91cf30%\uff0c\u6700\u540e1\u5468\u7ef4\u630150mg\/\u65e5\u3002<\/p>\n<p>2. \u66ff\u4ee3\u996e\u54c1\u9009\u62e9<br \/>\n\uff081\uff09\u4f4e\u56e0\u8336\uff1a\u8336\u591a\u915a\u4fdd\u7559\u7387\uff1e85%\uff0cEGCG\u542b\u91cf\u8fbe200mg\/\u676f<br \/>\n\uff082\uff09\u674f\u4ec1\u5976\uff1a\u9499\u542b\u91cf\uff08120mg\/\u676f\uff09\u662f\u725b\u5976\u76841.5\u500d<br \/>\n\uff083\uff09\u5947\u4e9a\u7c7d\u996e\u54c1\uff1a\u542b\u03c9-3\u8102\u80aa\u9178\uff08200mg\/\u676f\uff09<\/p>\n<p>3. \u8425\u517b\u534f\u540c\u5e72\u9884<br \/>\n\u8865\u5145\u53f6\u9178\uff08400-800\u03bcg\/\u65e5\uff09\u3001\u7ef4\u751f\u7d20B6\uff081.8-2.6mg\/\u65e5\uff09\u53ef\u63d0\u5347\u5496\u5561\u56e0\u4ee3\u8c22\u6548\u7387\u3002\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0c\u8054\u5408\u8865\u5145\u7ec4\uff08\u5496\u5561\u56e0+\u53f6\u9178\uff09\u7684\u534a\u8870\u671f\u7f29\u77ed23%\uff08p&lt;0.01\uff09\u3002<\/p>\n<p>\u4e94\u3001\u7279\u6b8a\u4eba\u7fa4\u7ba1\u7406\u8981\u70b9<br \/>\n\uff08\uff1a\u5496\u5561\u56e0\u8fc7\u654f\u8005 \u9ad8\u8840\u538b\u5b55\u5987 \u5fc3\u810f\u75c5\u5408\u5e76\u598a\u5a20\uff09<br \/>\n1. \u5496\u5561\u56e0\u8fc7\u654f\u5b55\u5987<br \/>\n\u9700\u5efa\u7acb&quot;\u5496\u5561\u56e0-\u75c7\u72b6&quot;\u65e5\u8bb0\uff0c\u8bb0\u5f55\u6444\u5165\u540e2\u5c0f\u65f6\u5fc3\u7387\uff08\u76ee\u6807\uff1c100\u6b21\/\u5206\uff09\u3001\u8840\u538b\uff08\u76ee\u6807\uff1c130\/80mmHg\uff09\u53d8\u5316\u3002\u5efa\u8bae\u91c7\u7528&quot;20-20-20&quot;\u539f\u5219\uff1a\u6bcf\u65e5\u52063\u6b21\u6444\u5165\uff0c\u6bcf\u6b21\u95f4\u969420\u5206\u949f\uff0c\u5355\u6b21\u4e0d\u8d85\u8fc720mg\u3002<\/p>\n<p>2. \u598a\u5a20\u671f\u9ad8\u8840\u538b\u7ba1\u7406<br \/>\n\u5bf9\u8840\u538b\u63a7\u5236\u4e0d\u4f73\u8005\uff0c\u5e94\u5b9e\u65bd\u5496\u5561\u56e0\u96f6\u6444\u5165\u3002\u76d1\u6d4b\u6570\u636e\u663e\u793a\uff0c\u4e25\u683c\u6212\u65ad\u7ec4\uff08n=152\uff09\u7684\u8840\u538b\u8fbe\u6807\u7387\uff08\uff1c140\/90mmHg\uff09\u8fbe82%\uff0c\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff08p&lt;0.001\uff09\u3002<\/p>\n<p>3. \u5fc3\u810f\u75c5\u5408\u5e76\u598a\u5a20<br 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