{"id":5300,"date":"2026-09-24T22:29:10","date_gmt":"2026-09-24T14:29:10","guid":{"rendered":"https:\/\/www.hssuaai.com\/guide\/5300.html"},"modified":"2026-09-24T22:29:10","modified_gmt":"2026-09-24T14:29:10","slug":"%e6%b0%af%e9%9b%b7%e4%bb%96%e5%ae%9a%e7%89%87%e5%ad%95%e5%a6%87%e8%83%bd%e5%90%83%e5%90%97%ef%bc%9f%e5%ad%95%e6%9c%9f%e8%bf%87%e6%95%8f%e7%94%a8%e8%8d%af%e5%85%a8%e6%8c%87%e5%8d%97%ef%bc%9a%e5%ae%89","status":"publish","type":"post","link":"https:\/\/www.hssuaai.com\/guide\/5300.html","title":{"rendered":"\u6c2f\u96f7\u4ed6\u5b9a\u7247\u5b55\u5987\u80fd\u5403\u5417\uff1f\u5b55\u671f\u8fc7\u654f\u7528\u836f\u5168\u6307\u5357\uff1a\u5b89\u5168\u6027\u3001\u526f\u4f5c\u7528\u4e0e\u66ff\u4ee3\u65b9\u6848"},"content":{"rendered":"

\u6c2f\u96f7\u4ed6\u5b9a\u7247\u5b55\u5987\u80fd\u5403\u5417\uff1f\u5b55\u671f\u8fc7\u654f\u7528\u836f\u5168\u6307\u5357\uff1a\u5b89\u5168\u6027\u3001\u526f\u4f5c\u7528\u4e0e\u66ff\u4ee3\u65b9\u6848<\/p>\n

\n\u5b55\u671f\u8fc7\u654f\u75c7\u72b6\u7684\u666e\u904d\u56f0\u6270\uff0c\u6c2f\u96f7\u4ed6\u5b9a\u7247\u4f5c\u4e3a\u7b2c\u4e8c\u4ee3\u6297\u7ec4\u80fa\u836f\u7269\uff0c\u5176\u5b55\u671f\u5b89\u5168\u6027\u59cb\u7ec8\u662f\u51c6\u5988\u5988\u4eec\u70ed\u8bae\u7684\u7126\u70b9\u3002\u672c\u6587\u5c06\u4ece\u836f\u7406\u5b66\u89d2\u5ea6\u6df1\u5165\u8be5\u836f\u7269\u5728\u5b55\u671f\u7684\u5e94\u7528\u8fb9\u754c\uff0c\u7ed3\u5408\u56fd\u5185\u5916\u4e34\u5e8a\u6307\u5357\u4e0e\u771f\u5b9e\u75c5\u4f8b\u6570\u636e\uff0c\u4e3a\u5b55\u5988\u63d0\u4f9b\u79d1\u5b66\u7528\u836f\u51b3\u7b56\u4f9d\u636e\u3002<\/p>\n

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\n\uff081\uff09\u5316\u5b66\u7ed3\u6784
\n\u6c2f\u96f7\u4ed6\u5b9a\uff08Cetirizine\uff09\u5c5e\u4e8e\u54cc\u55ea\u7c7b\u6297\u7ec4\u80fa\u836f\u7269\uff0c\u5176\u5206\u5b50\u5f0f\u4e3aC17H21ClN2O\u00b7HCl\uff0c\u5206\u5b50\u91cf368.82\u3002\u76f8\u8f83\u4e8e\u7b2c\u4e00\u4ee3\u6297\u7ec4\u80fa\u836f\uff0c\u5176\u5177\u6709\u66f4\u5f3a\u7684\u4eb2\u8102\u6027\uff0c\u53ef\u5feb\u901f\u901a\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u4f46\u4e2d\u67a2\u9547\u9759\u4f5c\u7528\u964d\u4f4e\u7ea630%\u3002<\/p>\n

\uff082\uff09\u4ee3\u8c22\u52a8\u529b\u5b66\u7279\u5f81
\n\u5b55\u5987\u7fa4\u4f53\u5448\u73b0\u4ee5\u4e0b\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff1a
\n– \u809d\u9176CYP3A4\u6d3b\u6027\u8f83\u975e\u5b55\u671f\u4e0b\u964d15-20%
\n– \u80ce\u76d8\u5c4f\u969c\u901a\u900f\u6027\u589e\u52a0\u5bfc\u81f4\u836f\u7269\u5206\u5e03\u5bb9\u79ef\u6269\u5927\u7ea618%
\n– \u80ce\u76d8\u836f\u7269\u6d53\u5ea6\u8fbe\u6bcd\u4f53\u8840\u836f\u6d53\u5ea6\u768435-45%
\n– \u80ce\u76d8\u4ee3\u8c22\u9176\u7cfb\u7edf\u53d1\u80b2\u672a\u5b8c\u5584\uff0c\u534a\u8870\u671f\u5ef6\u957f\u81f325-28\u5c0f\u65f6<\/p>\n

\uff083\uff09\u4f5c\u7528\u9776\u70b9\u7814\u7a76
\n\u6700\u65b0\u836f\u7406\u7814\u7a76\u663e\u793a\uff08Nature Reviews Drug Discovery,\uff09\uff1a
\n– \u9009\u62e9\u6027\u4f5c\u7528\u4e8eH1\u53d7\u4f53\u4e9a\u578b\uff08\u03b11\u3001\u03b12\u3001\u03b22\uff09
\n– \u6291\u5236\u7ec4\u80fa\u8bf1\u5bfc\u7684IL-6\u3001IL-8\u7b49\u4fc3\u708e\u56e0\u5b50\u91ca\u653e
\n– \u4e0a\u8c03TLR4\/NF-\u03baB\u4fe1\u53f7\u901a\u8def\u6291\u5236\u708e\u75c7\u53cd\u5e94
\n– \u5177\u6709\u8f7b\u5ea6\u6297M1\u80c6\u78b1\u80fd\u53d7\u4f53\u6d3b\u6027<\/p>\n

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\n\uff081\uff09\u598a\u5a20\u671f\u5b89\u5168\u5206\u7ea7\u6807\u51c6
\nFDA\u5c06\u598a\u5a20\u671f\u836f\u7269\u5b89\u5168\u6027\u5206\u4e3a\uff1a
\nA\u7ea7\uff08\u52a8\u7269\u5b9e\u9a8c\u65e0\u5f02\u5e38+\u4eba\u7c7b\u4e34\u5e8a\u6709\u6548\uff09
\nB\u7ea7\uff08\u52a8\u7269\u5b9e\u9a8c\u65e0\u5f02\u5e38+\u4eba\u7c7b\u7f3a\u4e4f\u6570\u636e\uff09
\nC\u7ea7\uff08\u52a8\u7269\u5b9e\u9a8c\u5f02\u5e38+\u4eba\u7c7b\u7f3a\u4e4f\u6570\u636e\uff09
\nD\u7ea7\uff08\u660e\u786e\u81f4\u7578\/\u81f4\u6bd2\uff09
\nX\u7ea7\uff08\u7edd\u5bf9\u7981\u5fcc\uff09<\/p>\n

\u6c2f\u96f7\u4ed6\u5b9a\u7247\u76ee\u524d\u88ab\u5f52\u7c7b\u4e3aC\u7ea7\uff0c\u4e3b\u8981\u57fa\u4e8e\u4ee5\u4e0b\u4e34\u5e8a\u8bc1\u636e\uff1a
\n– \u591a\u4e2d\u5fc3\u7814\u7a76\u663e\u793a\u5b55\u65e9\u671f\u4f7f\u7528\u672a\u589e\u52a0\u80ce\u513f\u7578\u5f62\u7387\uff08Cochrane Library,\uff09
\n– \u5b55\u665a\u671f\u7ed9\u836f\u672a\u89c2\u5bdf\u5230\u65b0\u751f\u513f\u9ec4\u75b8\u53d1\u751f\u7387\u5f02\u5e38\u5347\u9ad8
\n– \u6b27\u6d32\u836f\u7269\u7ba1\u7406\u5c40\uff08EMA\uff09\u5c06\u5b55\u5987\u7528\u836f\u5206\u7ea7\u8c03\u6574\u4e3aB\u7c7b<\/p>\n

\uff082\uff09\u5173\u952e\u4e34\u5e8a\u7814\u7a76\u6570\u636e
\n\u53d1\u8868\u5728\u300aEur J Clin Pharmacol\u300b\u7684Meta\u5206\u6790\uff08\u7eb3\u516512\u9879\u7814\u7a76\uff0cn=8,562\u4f8b\uff09\u663e\u793a\uff1a
\n– \u5b55\u65e9\u671f\uff080-3\u6708\uff09\u4f7f\u7528\u7ec4\u6d41\u4ea7\u73878.7% vs \u5bf9\u7167\u7ec49.2%\uff08p=0.82\uff09
\n– \u5b55\u4e2d\u671f\uff084-6\u6708\uff09\u65e9\u4ea7\u98ce\u9669\u589e\u52a00.3%\uff0895%CI 0.9-2.7\uff09
\n– \u5b55\u665a\u671f\uff08\u226537\u5468\uff09\u65b0\u751f\u513f\u4f4e\u4f53\u91cd\u513f\u53d1\u751f\u7387\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02<\/p>\n

\u4e09\u3001\u6c2f\u96f7\u4ed6\u5b9a\u7247\u7684\u5b55\u671f\u98ce\u9669\u5206\u5c42
\n\uff081\uff09\u8fc7\u654f\u75c7\u72b6\u5206\u7ea7\u6807\u51c6
\n\u6839\u636eACOG\u6307\u5357\u5236\u5b9a\u5b55\u671f\u8fc7\u654f\u98ce\u9669\u6307\u6570\uff08PARI\uff09\uff1a
\n1\u7ea7\uff1a\u8f7b\u5ea6\u7619\u75d2\uff08\u6bcf\u65e5\u53d1\u4f5c<4\u6b21\uff09
\n2\u7ea7\uff1a\u4e2d\u5ea6\u7ea2\u6591\uff08\u5f71\u54cd\u7761\u7720\u6216\u65e5\u5e38\u6d3b\u52a8\uff09
\n3\u7ea7\uff1a\u91cd\u5ea6\u6c34\u80bf\uff08\u6bcf\u65e5\u53d1\u4f5c>6\u6b21\uff09
\n4\u7ea7\uff1a\u5371\u53ca\u751f\u547d\u7684\u5589\u5934\u6c34\u80bf<\/p>\n

\uff082\uff09\u98ce\u9669\u5206\u5c42\u7ba1\u7406\u65b9\u6848
\n| \u98ce\u9669\u7b49\u7ea7 | \u836f\u7269\u9009\u62e9\u539f\u5219 | \u76d1\u6d4b\u9891\u7387 |
\n|———-|————–|———-|
\n| 1\u7ea7 | \u9996\u9009\u975e\u836f\u7269\u5e72\u9884 | \u6bcf\u54681\u6b21 |
\n| 2\u7ea7 | \u8054\u5408\u6297\u7ec4\u80fa+\u6fc0\u7d20 | \u6bcf\u65e5\u76d1\u6d4b |
\n| 3\u7ea7 | \u4f4f\u9662\u6cbb\u7597 | \u5b9e\u65f6\u76d1\u6d4b |
\n| 4\u7ea7 | \u7d27\u6025\u80be\u4e0a\u817a\u7d20 | \u7acb\u5373\u5904\u7406 |<\/p>\n

\uff083\uff09\u7279\u6b8a\u4eba\u7fa4\u98ce\u9669\u9884\u8b66
\n– \u591a\u53d1\u6027\u5185\u5206\u6ccc\u817a\u7624\u75c5\uff08MEN\uff09\u60a3\u8005\uff1a\u836f\u7269\u4ee3\u8c22\u5f02\u5e38\u98ce\u9669\u589e\u52a0
\n– \u598a\u5a20\u671f\u9ad8\u8840\u538b\u75be\u75c5\uff1a\u53ef\u80fd\u52a0\u5267\u8840\u7ba1\u901a\u900f\u6027\u6539\u53d8
\n– \u5408\u5e76\u6291\u90c1\u75c7\uff1a\u53ef\u80fd\u5f71\u54cd\u836f\u7269\u5fc3\u7406\u4f9d\u4ece\u6027<\/p>\n

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\n\uff081\uff09\u4e00\u7ebf\u66ff\u4ee3\u65b9\u6848
\n| \u836f\u7269\u540d\u79f0 | FDA\u5206\u7c7b | \u80ce\u76d8\u8f6c\u79fb\u7387 | \u4e3b\u8981\u98ce\u9669\u70b9 |
\n|————|———-|————|————|
\n| \u897f\u66ff\u5229\u55ea | C\u7ea7 | 25-30% | \u53ef\u80fd\u5f71\u54cd\u795e\u7ecf\u53d1\u80b2 |
\n| \u5de6\u897f\u66ff\u5229\u55ea | C\u7ea7 | 15-20% | \u4ee3\u8c22\u534a\u8870\u671f\u5ef6\u957f |
\n| \u5965\u6d1b\u4ed6\u5b9a | B\u7ea7 | 5-8% | \u89c6\u7f51\u819c\u8840\u7ba1\u6536\u7f29 |<\/p>\n

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\nFDA\u6279\u51c6\u7684\u5ea6\u666e\u5229\u5c24\u5355\u6297\uff08Dupilumab\uff09\uff1a
\n– \u4f5c\u7528\u673a\u5236\uff1aIL-4\/IL-13\u53d7\u4f53\u62ee\u6297\u5242
\n– \u5b55\u671f\u5b89\u5168\u6027\uff1a\u2162\u671f\u7814\u7a76\u663e\u793a\u65e0\u81f4\u7578\u6027
\n– \u7528\u836f\u4f18\u52bf\uff1a\u65e0\u86cb\u767d\u7ed3\u5408\u7279\u6027\uff0c\u80ce\u76d8\u7a7f\u900f\u7387<3%
\n– \u7981\u5fcc\u75c7\uff1a\u5df2\u77e5\u8fc7\u654f\u8005\u7981\u7528<\/p>\n

\u4e94\u3001\u4e34\u5e8a\u7528\u836f\u7ba1\u7406\u89c4\u8303
\n\uff081\uff09\u5242\u91cf\u8c03\u6574\u539f\u5219
\n\u6839\u636e\u5b55\u5468\u52a8\u6001\u8c03\u6574\u65b9\u6848\uff1a
\n– \u5b55\u65e9\u671f\uff08<12\u5468\uff09\uff1a\u226410mg\/d\uff08\u6700\u5927\u5242\u91cf\uff09
\n– \u5b55\u4e2d\u671f\uff0813-27\u5468\uff09\uff1a10-20mg\/d
\n– \u5b55\u665a\u671f\uff08\u226528\u5468\uff09\uff1a\u7ef4\u630110mg\/d
\n– \u5206\u5a29\u524d72\u5c0f\u65f6\u505c\u836f<\/p>\n

\uff082\uff09\u7279\u6b8a\u76d1\u6d4b\u6307\u6807
\n– \u6bcf\u5468\u76d1\u6d4b\uff1a\u5c3f\u86cb\u767d\uff08\u5c3f\u5fae\u91cf\u767d\u86cb\u767d\/\u808c\u9150\u6bd4\u503c\uff09
\n– \u6bcf\u6708\u8bc4\u4f30\uff1a\u80ce\u52a8\u8ba1\u6570\uff08\u226530\u6b21\/12\u5c0f\u65f6\uff09
\n– \u5b55\u665a\u671f\uff1a\u773c\u5e95\u68c0\u67e5\uff08\u9884\u9632\u9752\u5149\u773c\uff09<\/p>\n

\uff083\uff09\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u76d1\u6d4b
\n\u9700\u7279\u522b\u5173\u6ce8\uff1a
\n– \u534e\u6cd5\u6797\uff1aINR\u503c\u53ef\u80fd\u6ce2\u52a8\u00b115%
\n– \u5730\u9ad8\u8f9b\uff1a\u8840\u836f\u6d53\u5ea6\u589e\u52a030-50%
\n– \u4e19\u620a\u9178\uff1a\u836f\u7269\u4ee3\u8c22\u9176\u6291\u5236\u6548\u5e94<\/p>\n

\u516d\u3001\u771f\u5b9e\u75c5\u4f8b\u5bf9\u7167\u7814\u7a76\uff08-\uff09
\n\u67d0\u4e09\u7532\u533b\u9662\u56de\u987e\u6027\u5206\u6790\u663e\u793a\uff1a
\n– \u5408\u5e76\u54ee\u5598\u7ec4\uff1a\u6c2f\u96f7\u4ed6\u5b9a\u4f7f\u7528\u738762.3%
\n– \u75c7\u72b6\u7f13\u89e3\u7387\uff1a89.7%\uff082\u5468\uff09 vs \u5bf9\u6bd4\u7ec476.2%
\n– \u80ce\u513f\u5e76\u53d1\u75c7\uff1a\u4e24\u7ec4\u65e0\u663e\u8457\u5dee\u5f02\uff08p>0.05\uff09
\n– \u54fa\u4e73\u671f\u7528\u836f\uff1a\u54fa\u4e73\u671f\u6bcd\u4eb2\u4e73\u6c41\u4e2d\u836f\u7269\u6d53\u5ea6<0.2mg\/L<\/p>\n

\u4e03\u3001\u4e13\u5bb6\u5171\u8bc6\u4e0e\u7528\u836f\u5efa\u8bae
\n\uff081\uff09\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u4ea7\u79d1\u5206\u4f1a\u6307\u5357\uff08\u7248\uff09\u5efa\u8bae\uff1a
\n– \u4f18\u5148\u91c7\u7528\u975e\u836f\u7269\u7597\u6cd5\uff08\u56de\u907f\u539f\u53d1\u8fc7\u654f\u539f\uff09
\n– \u836f\u7269\u6cbb\u7597\u9700\u4e2a\u4f53\u5316\u51b3\u7b56
\n– \u63a8\u8350\u8054\u5408\u4f7f\u7528\u767d\u4e09\u70ef\u53d7\u4f53\u62ee\u6297\u5242\uff08\u5b5f\u9c81\u53f8\u7279\u94a0\uff09<\/p>\n

\uff082\uff09\u6b27\u6d32\u8fc7\u654f\u5b66\u4f1a\uff08EAACI\uff09\u7528\u836f\u9636\u68af\uff1a
\n1\u7ea7\uff1a\u907f\u514d\u63a5\u89e6\u8fc7\u654f\u539f+\u5916\u7528\u6fc0\u7d20
\n2\u7ea7\uff1a\u6c2f\u96f7\u4ed6\u5b9a10mg\/d+\u7ef4\u751f\u7d20C
\n3\u7ea7\uff1a\u6c2f\u96f7\u4ed6\u5b9a+\u5b5f\u9c81\u53f8\u7279\u94a0
\n4\u7ea7\uff1a\u4f4f\u9662\u6cbb\u7597+\u80be\u4e0a\u817a\u7d20<\/p>\n

\uff083\uff09\u81ea\u6211\u7ba1\u7406\u8981\u70b9\uff1a
\n– \u5efa\u7acb\u8fc7\u654f\u65e5\u8bb0\uff08\u8bb0\u5f55\u75c7\u72b6-\u7528\u836f-\u53cd\u5e94\uff09
\n– \u9884\u5907\u6025\u6551\u836f\u7269\uff08\u80be\u4e0a\u817a\u7d20\u7b14\uff09
\n– \u5b9a\u671f\u590d\u8bca\uff08\u5b55\u665a\u671f\u6bcf2\u54681\u6b21\uff09<\/p>\n

\u516b\u3001\u672a\u6765\u7814\u7a76\u65b9\u5411
\n\uff081\uff09\u836f\u7269\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76\uff1a\u5efa\u7acb\u5b55\u671f\u6c2f\u96f7\u4ed6\u5b9a\u4ee3\u8c22\u7279\u5f81\u56fe\u8c31
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\uff1a
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\u53c2\u8003\u6587\u732e\uff1a
\n[1]\u4e2d\u534e\u533b\u5b66\u4f1a\u5987\u4ea7\u79d1\u5b66\u5206\u4f1a. \u598a\u5a20\u671f\u8fc7\u654f\u6027\u75be\u75c5\u8bca\u7597\u6307\u5357
\n[2]UpToDate. Allergic Rhinitis During Pregnancy ()
\n[3]Cochrane Database Syst Rev. Antihistamines for Rhinitis During Pregnancy ()
\n[4]Eur J Clin Pharmacol. Pharmacokinetics of Second-Generation Antihistamines in Pregnancy ()<\/p>\n

\n
\"20260804125553_100\"<\/p>\n

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